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Pharmacy and nursing · Study chart

Sig codes and prescription abbreviations

What qhs, qd, hs, NPO, prn, gtt, ac and the rest mean: the Latin, the plain meaning, where each is written in an order, and the “Do Not Use” and error-prone flags with what to write instead. Free, and for study only.

  • 140 sig codes
  • Latin and plain meaning
  • Do Not Use flags
  • No sign-up needed

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1 · Look up a sig code

What does that abbreviation mean?

Type a code as it is written on a prescription or an order (qhs, NPO, q4h, gtt), or a word from its meaning (bedtime, drops, each eye). Each answer gives the plain meaning, the Latin where there is one, where it is written, and any Joint Commission “Do Not Use” or ISMP error-prone flag with what to write instead.

Common searches

140 codes in the list. The ones people look up most are answered below; search for any other.

Quick answers

  • qhs

    quaque hora somni

    every night at bedtime

    Error-prone. Write QHS or qhs, ISMP’s 2024 wording for bedtime (not HS, not “nightly”).

  • NPO

    nil per os

    nothing by mouth: no food or drink

    Route: how it goes in

  • qd

    quaque die

    every day, daily

    Do not use. Write daily.

  • hs

    hora somni

    at bedtime (hour of sleep)

    Caution. Write QHS or qhs (ISMP’s 2024 update: do not use HS or “nightly” for bedtime).

  • prn

    pro re nata (s.o.s.: si opus sit, if there is need)

    as needed

    When, and on what condition

  • gtt

    gutta (gtts: guttae)

    drop; gtts, drops

    Form: what it is

  • ac

    ante cibum

    before meals

    When, and on what condition

  • pc

    post cibum

    after meals

    When, and on what condition

  • qod

    on the Minnesota sheet also q.a.d. (quoque alternis die) and dieb. alt. (diebus alternis)

    every other day

    Do not use. Write every other day.

  • OD

    oculus dexter

    right eye

    Error-prone. Write right eye.

  • OU

    oculus uterque

    each eye, both eyes

    Error-prone. Write each eye.

  • po

    per os

    by mouth, orally

    Route: how it goes in

Tap a code above, or type it, for the full entry with the Latin and where it is written.

2 · Where each code is written

How a sig line reads

The sig (Latin signa, write on label) is the directions part of a prescription: what the pharmacy prints on the label. Its codes usually come in the same order, so once the slots are familiar a sig line is easy to read. The examples name no drug and are for study only.

  1. 1

    How often

    After the route in the sig: 1 tab PO bid.

  2. 2

    When, and on what condition

    Usually the last part of the sig: 1 tab PO bid pc, 1 tab PO qhs, 1 cap PO q8h prn.

  3. 3

    Route: how it goes in

    After the form in the sig: 1 tab PO bid, 2 gtt OU qid.

  4. 4

    Form: what it is

    Right after the amount in the sig: 1 tab, 2 gtt, 1 supp.

  5. 5

    Amount and units

    The first part of the sig, and the strength on the drug line: 10 mg, 5 mL, 2 gtt.

Outside the sig, the instruction words and symbols fill the rest of the prescription: the label line (sig), the quantity (disp), refills (non rep), substitution (DAW), and the compounding words (q.s., aa, M.).

  • 1 tab PO bid pc

    • 1Amount and units
    • tabForm: what it is
    • PORoute: how it goes in
    • bidHow often
    • pcWhen, and on what condition

    Reads: one tablet by mouth, twice a day, after meals.

  • 2 gtt OU qid

    • 2Amount and units
    • gttForm: what it is
    • OURoute: how it goes in
    • qidHow often

    Reads: two drops in each eye, four times a day.

    ISMP: write “each eye”, not OU, which is mistaken for AU (each ear).

  • 1 cap PO q8h prn

    • 1Amount and units
    • capForm: what it is
    • PORoute: how it goes in
    • q8hHow often
    • prnWhen, and on what condition

    Reads: one capsule by mouth, every 8 hours, as needed (a prn direction also names the reason).

  • ss tab PO qhs

    • ssAmount and units
    • tabForm: what it is
    • PORoute: how it goes in
    • qhsWhen, and on what condition

    Reads: half a tablet by mouth, every night at bedtime.

    ISMP: write “half tablet” in words (a handwritten ss has been read as 55), and QHS or qhs for bedtime, never HS.

3 · How often and when

The frequency and timing chart

Every “how often” and “when” code, with its Latin and how many doses that is in a day. The counts are arithmetic, not a schedule: a facility sets its own standard times, and qid (four doses in a day) is not the same as q6h (one dose every 6 hours).

CodeMeaningIn a day
qhquaque horaevery hour24 in a day
q2hquaque 2 horaevery 2 hours12 in a day
q3hquaque 3 horaevery 3 hours8 in a day
q4hquaque 4 hora (qqh: quater quaque hora)every 4 hours6 in a day
q6hquaque 6 horaevery 6 hours4 in a day
q8hquaque 8 horaevery 8 hours3 in a day
q12hquaque 12 horaevery 12 hours2 in a day
alt. h.alternis horisevery other hour12 in a day
qdquaque dieevery day, dailyDo not use: write daily.1 in a day
q1ddailyError-prone: write daily.1 in a day
o.d.once daily (the same letters also mean right eye)Error-prone: write daily.1 in a day
SIDsometimes written for once a dayCaution: write daily.1 in a day
bidbis in dietwice a day2 in a day
tidter in die (t.d.s.: ter die sumendum)three times a day3 in a day
qidquater in die (q.d.s.: quater die sumendus)four times a day4 in a day
qodon the Minnesota sheet also q.a.d. (quoque alternis die) and dieb. alt. (diebus alternis)every other dayDo not use: write every other day.1 every 2 days
qwkevery week1 a week
tiwthree times a weekError-prone: write 3 times weekly.3 a week
biwtwo times a weekError-prone: write 2 times weekly.2 a week
ATCaround the clockspaced evenly through 24 hours
x1once, one doseError-prone: write explicit words, such as “for 1 dose”.1, then stop
statstatimimmediately, right nowonce, now
prnpro re nata (s.o.s.: si opus sit, if there is need)as neededonly when needed
acante cibumbefore mealsbefore each meal
pcpost cibumafter mealsafter each meal
cfwith foodwith food
qamquaque die ante meridiemevery morning (every day before noon)1 in a day, morning
qpmquaque die post meridiemevery evening (every day after noon)1 in a day, evening
qhsquaque hora somnievery night at bedtimeError-prone: write QHS or qhs, ISMP’s 2024 wording for bedtime (not HS, not “nightly”).1 in a day, bedtime
hshora somniat bedtime (hour of sleep)Caution: write QHS or qhs (ISMP’s 2024 update: do not use HS or “nightly” for bedtime).1 in a day, bedtime
qnnightly, at bedtimeError-prone: write QHS or qhs.1 in a day, night
BTbedtimeCaution: write QHS or qhs (ISMP’s bedtime wording).1 in a day, bedtime
noctnocteat nightat night
q6PMevery evening at 6 PMError-prone: write daily at 6 PM, or 6 PM daily.1 in a day, 6 PM
ad libad libitumas much as desired, freelyno fixed count

4 · The safety list

The Joint Commission “Do Not Use” list

Applies to all orders and all medication-related documentation that is handwritten (including free-text computer entry) or on pre-printed forms. A trailing zero may be used only where it is needed to show the precision of a value, such as a lab result, an imaging size or a catheter or tube size; never in a medication order. ISMP keeps a longer list of error-prone abbreviations; the lookup above flags both.

Do not useProblemWrite instead
U, u (unit)Mistaken for 0 (zero), the number 4, or ccWrite “unit”
IU (International Unit)Mistaken for IV (intravenous) or the number 10Write “International Unit”
Q.D., QD, q.d., qd (daily)Mistaken for each other: the period after the Q is read as an I, and the O as an IWrite “daily”
Q.O.D., QOD, q.o.d, qod (every other day)Mistaken for each other, in the same wayWrite “every other day”
Trailing zero (X.0 mg)The decimal point is missedWrite X mg
Lack of leading zero (.X mg)The decimal point is missedWrite 0.X mg
MS, MSO4 and MgSO4Shorthand for two different sulfate medicines, confused for one anotherWrite the full drug name

5 · Practice questions

20 practice questions

The codes people look up most, the Latin behind them, where each is written and the two safety lists, multiple choice, one at a time. Every answer is explained, and your result is free: no sign-up needed.

Question 1 of 20

qhs means

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The rest of the chart

Medical abbreviations and terms decoderThe charting abbreviations (WNL, NKDA, SOB, A&O x3), a word-part decoder, flashcards and practice questions.

Sources

Where the facts come from

Every meaning, Latin origin and flag on this page is reworded from one of these public sources. Check anything important against your program’s materials and your facility’s own approved list.

Questions

Common questions

Every night at bedtime, from the Latin quaque hora somni. It is the bedtime code ISMP’s 2024 list says to write (QHS or qhs). ISMP’s update says not to use the older HS, or the word “nightly”, for bedtime, because HS has also meant half-strength.

Nothing by mouth, from the Latin nil per os: no food or drink. It is an order rather than a label direction, common before surgery and some procedures, and it usually carries a start time, such as “NPO after midnight”.

Every day, daily (quaque die). A handwritten qd is misread as qid, four times a day, when the period after the q or the tail of the q looks like an i, and it is also confused with qod. The Joint Commission list says to write the word “daily”.

Both mean at bedtime: hs is hora somni, the hour of sleep, and qhs is quaque hora somni, every night at bedtime. HS has also been used for half-strength, so ISMP’s 2024 update says not to use HS (or “nightly”) for bedtime and to write QHS or qhs instead.

As needed, from pro re nata. A prn direction is not on a fixed schedule: it names the reason and the limit, for example “every 6 hours as needed for pain”. ATC, around the clock, is the opposite: doses spaced evenly through the day.

ac is ante cibum, before meals; pc is post cibum, after meals. They are timing codes and usually come last in a sig line, after how often: 1 tab PO bid pc is one tablet by mouth, twice a day, after meals.

Drop, from the Latin gutta; gtts (guttae) is drops. Eye and ear drops are counted this way, so 2 gtt OU would be two drops in each eye, and ISMP says to write “each eye” rather than OU, which is mistaken for AU, each ear.

Right eye, left eye and each eye: oculus dexter, oculus sinister and oculus uterque. The ears are AD, AS and AU (auris dextra, sinistra, utraque). Because the two sets are mistaken for each other, and OD has also meant once daily, ISMP’s list says to write the words.

Every other day. It is on the Joint Commission “Do Not Use” list because a poorly written o makes it look like qd (daily) or qid (four times a day): write “every other day”.

No. This is a study aid for people in pharmacy technician, medical assisting, nursing, billing and coding and health information programs, and for staff who read orders. It does not name a drug, does not tell anyone what to take or give, and your program’s materials and your facility’s own approved abbreviation list come first.

The lookup, the quick answers, the sig examples, the frequency chart, the “Do Not Use” list and the 20 practice questions with your result are free with no sign-up. An email unlocks the bonus: the printable chart and 30 more questions.