Pharmacy and nursing · Study chart
Sig codes and prescription abbreviations
What qhs, qd, hs, NPO, prn, gtt, ac and the rest mean: the Latin, the plain meaning, where each is written in an order, and the “Do Not Use” and error-prone flags with what to write instead. Free, and for study only.
- 140 sig codes
- Latin and plain meaning
- Do Not Use flags
- No sign-up needed
CollegeCompass360 is an independent education resource. We are not a school, a testing company or a government agency.
1 · Look up a sig code
What does that abbreviation mean?
Type a code as it is written on a prescription or an order (qhs, NPO, q4h, gtt), or a word from its meaning (bedtime, drops, each eye). Each answer gives the plain meaning, the Latin where there is one, where it is written, and any Joint Commission “Do Not Use” or ISMP error-prone flag with what to write instead.
Common searches
140 codes in the list. The ones people look up most are answered below; search for any other.
Quick answers
qhs
quaque hora somni
every night at bedtime
Error-prone. Write QHS or qhs, ISMP’s 2024 wording for bedtime (not HS, not “nightly”).
NPO
nil per os
nothing by mouth: no food or drink
Route: how it goes in
qd
quaque die
every day, daily
Do not use. Write daily.
hs
hora somni
at bedtime (hour of sleep)
Caution. Write QHS or qhs (ISMP’s 2024 update: do not use HS or “nightly” for bedtime).
prn
pro re nata (s.o.s.: si opus sit, if there is need)
as needed
When, and on what condition
gtt
gutta (gtts: guttae)
drop; gtts, drops
Form: what it is
ac
ante cibum
before meals
When, and on what condition
pc
post cibum
after meals
When, and on what condition
qod
on the Minnesota sheet also q.a.d. (quoque alternis die) and dieb. alt. (diebus alternis)
every other day
Do not use. Write every other day.
OD
oculus dexter
right eye
Error-prone. Write right eye.
OU
oculus uterque
each eye, both eyes
Error-prone. Write each eye.
po
per os
by mouth, orally
Route: how it goes in
Tap a code above, or type it, for the full entry with the Latin and where it is written.
2 · Where each code is written
How a sig line reads
The sig (Latin signa, write on label) is the directions part of a prescription: what the pharmacy prints on the label. Its codes usually come in the same order, so once the slots are familiar a sig line is easy to read. The examples name no drug and are for study only.
1
How often
After the route in the sig: 1 tab PO bid.
2
When, and on what condition
Usually the last part of the sig: 1 tab PO bid pc, 1 tab PO qhs, 1 cap PO q8h prn.
3
Route: how it goes in
After the form in the sig: 1 tab PO bid, 2 gtt OU qid.
4
Form: what it is
Right after the amount in the sig: 1 tab, 2 gtt, 1 supp.
5
Amount and units
The first part of the sig, and the strength on the drug line: 10 mg, 5 mL, 2 gtt.
Outside the sig, the instruction words and symbols fill the rest of the prescription: the label line (sig), the quantity (disp), refills (non rep), substitution (DAW), and the compounding words (q.s., aa, M.).
1 tab PO bid pc
- 1Amount and units
- tabForm: what it is
- PORoute: how it goes in
- bidHow often
- pcWhen, and on what condition
Reads: one tablet by mouth, twice a day, after meals.
2 gtt OU qid
- 2Amount and units
- gttForm: what it is
- OURoute: how it goes in
- qidHow often
Reads: two drops in each eye, four times a day.
ISMP: write “each eye”, not OU, which is mistaken for AU (each ear).
1 cap PO q8h prn
- 1Amount and units
- capForm: what it is
- PORoute: how it goes in
- q8hHow often
- prnWhen, and on what condition
Reads: one capsule by mouth, every 8 hours, as needed (a prn direction also names the reason).
ss tab PO qhs
- ssAmount and units
- tabForm: what it is
- PORoute: how it goes in
- qhsWhen, and on what condition
Reads: half a tablet by mouth, every night at bedtime.
ISMP: write “half tablet” in words (a handwritten ss has been read as 55), and QHS or qhs for bedtime, never HS.
3 · How often and when
The frequency and timing chart
Every “how often” and “when” code, with its Latin and how many doses that is in a day. The counts are arithmetic, not a schedule: a facility sets its own standard times, and qid (four doses in a day) is not the same as q6h (one dose every 6 hours).
| Code | Meaning | In a day |
|---|---|---|
| qhquaque hora | every hour | 24 in a day |
| q2hquaque 2 hora | every 2 hours | 12 in a day |
| q3hquaque 3 hora | every 3 hours | 8 in a day |
| q4hquaque 4 hora (qqh: quater quaque hora) | every 4 hours | 6 in a day |
| q6hquaque 6 hora | every 6 hours | 4 in a day |
| q8hquaque 8 hora | every 8 hours | 3 in a day |
| q12hquaque 12 hora | every 12 hours | 2 in a day |
| alt. h.alternis horis | every other hour | 12 in a day |
| qdquaque die | every day, dailyDo not use: write daily. | 1 in a day |
| q1d | dailyError-prone: write daily. | 1 in a day |
| o.d. | once daily (the same letters also mean right eye)Error-prone: write daily. | 1 in a day |
| SID | sometimes written for once a dayCaution: write daily. | 1 in a day |
| bidbis in die | twice a day | 2 in a day |
| tidter in die (t.d.s.: ter die sumendum) | three times a day | 3 in a day |
| qidquater in die (q.d.s.: quater die sumendus) | four times a day | 4 in a day |
| qodon the Minnesota sheet also q.a.d. (quoque alternis die) and dieb. alt. (diebus alternis) | every other dayDo not use: write every other day. | 1 every 2 days |
| qwk | every week | 1 a week |
| tiw | three times a weekError-prone: write 3 times weekly. | 3 a week |
| biw | two times a weekError-prone: write 2 times weekly. | 2 a week |
| ATC | around the clock | spaced evenly through 24 hours |
| x1 | once, one doseError-prone: write explicit words, such as “for 1 dose”. | 1, then stop |
| statstatim | immediately, right now | once, now |
| prnpro re nata (s.o.s.: si opus sit, if there is need) | as needed | only when needed |
| acante cibum | before meals | before each meal |
| pcpost cibum | after meals | after each meal |
| cf | with food | with food |
| qamquaque die ante meridiem | every morning (every day before noon) | 1 in a day, morning |
| qpmquaque die post meridiem | every evening (every day after noon) | 1 in a day, evening |
| qhsquaque hora somni | every night at bedtimeError-prone: write QHS or qhs, ISMP’s 2024 wording for bedtime (not HS, not “nightly”). | 1 in a day, bedtime |
| hshora somni | at bedtime (hour of sleep)Caution: write QHS or qhs (ISMP’s 2024 update: do not use HS or “nightly” for bedtime). | 1 in a day, bedtime |
| qn | nightly, at bedtimeError-prone: write QHS or qhs. | 1 in a day, night |
| BT | bedtimeCaution: write QHS or qhs (ISMP’s bedtime wording). | 1 in a day, bedtime |
| noctnocte | at night | at night |
| q6PM | every evening at 6 PMError-prone: write daily at 6 PM, or 6 PM daily. | 1 in a day, 6 PM |
| ad libad libitum | as much as desired, freely | no fixed count |
4 · The safety list
The Joint Commission “Do Not Use” list
Applies to all orders and all medication-related documentation that is handwritten (including free-text computer entry) or on pre-printed forms. A trailing zero may be used only where it is needed to show the precision of a value, such as a lab result, an imaging size or a catheter or tube size; never in a medication order. ISMP keeps a longer list of error-prone abbreviations; the lookup above flags both.
| Do not use | Problem | Write instead |
|---|---|---|
| U, u (unit) | Mistaken for 0 (zero), the number 4, or cc | Write “unit” |
| IU (International Unit) | Mistaken for IV (intravenous) or the number 10 | Write “International Unit” |
| Q.D., QD, q.d., qd (daily) | Mistaken for each other: the period after the Q is read as an I, and the O as an I | Write “daily” |
| Q.O.D., QOD, q.o.d, qod (every other day) | Mistaken for each other, in the same way | Write “every other day” |
| Trailing zero (X.0 mg) | The decimal point is missed | Write X mg |
| Lack of leading zero (.X mg) | The decimal point is missed | Write 0.X mg |
| MS, MSO4 and MgSO4 | Shorthand for two different sulfate medicines, confused for one another | Write the full drug name |
5 · Practice questions
20 practice questions
The codes people look up most, the Latin behind them, where each is written and the two safety lists, multiple choice, one at a time. Every answer is explained, and your result is free: no sign-up needed.
Question 1 of 20
qhs means
Bonus · unlocks with your email
The printable sig chart and 30 more questions
- Printable sig chart: all 140 codes on this page in order of where they are written (how often, when, route, form, amount, instruction words), each with its Latin and its flag, with the Joint Commission “Do Not Use” list on top. It prints on its own, two to three pages.
- 30 more practice questions, every answer explained: the routes, forms, units, symbols and instruction words the free set leaves out.
Enter your email in the box above and the bonus opens right here, and stays open on this browser.
More free study tools
The rest of the chart
Medical abbreviations and terms decoderThe charting abbreviations (WNL, NKDA, SOB, A&O x3), a word-part decoder, flashcards and practice questions.Sources
Where the facts come from
Every meaning, Latin origin and flag on this page is reworded from one of these public sources. Check anything important against your program’s materials and your facility’s own approved list.
- ISMP: List of Error-Prone Abbreviations, Symbols, and Dose Designations (2024 edition, PDF)
- ISMP: 2024 update to the error-prone list (bedtime is written QHS or qhs)
- The Joint Commission: Facts about the “Do Not Use” list
- Minnesota Board of Pharmacy: Partial list of prescription abbreviations (the Latin)
- NIH MedlinePlus: Abbreviations (Appendix B)
- ISMP Consumer Med Safety: Learn to read a prescription
- Merriam-Webster: signa
- Merriam-Webster Medical: NPO (nil per os)
Questions
Common questions
Every night at bedtime, from the Latin quaque hora somni. It is the bedtime code ISMP’s 2024 list says to write (QHS or qhs). ISMP’s update says not to use the older HS, or the word “nightly”, for bedtime, because HS has also meant half-strength.
Nothing by mouth, from the Latin nil per os: no food or drink. It is an order rather than a label direction, common before surgery and some procedures, and it usually carries a start time, such as “NPO after midnight”.
Every day, daily (quaque die). A handwritten qd is misread as qid, four times a day, when the period after the q or the tail of the q looks like an i, and it is also confused with qod. The Joint Commission list says to write the word “daily”.
Both mean at bedtime: hs is hora somni, the hour of sleep, and qhs is quaque hora somni, every night at bedtime. HS has also been used for half-strength, so ISMP’s 2024 update says not to use HS (or “nightly”) for bedtime and to write QHS or qhs instead.
As needed, from pro re nata. A prn direction is not on a fixed schedule: it names the reason and the limit, for example “every 6 hours as needed for pain”. ATC, around the clock, is the opposite: doses spaced evenly through the day.
ac is ante cibum, before meals; pc is post cibum, after meals. They are timing codes and usually come last in a sig line, after how often: 1 tab PO bid pc is one tablet by mouth, twice a day, after meals.
Drop, from the Latin gutta; gtts (guttae) is drops. Eye and ear drops are counted this way, so 2 gtt OU would be two drops in each eye, and ISMP says to write “each eye” rather than OU, which is mistaken for AU, each ear.
Right eye, left eye and each eye: oculus dexter, oculus sinister and oculus uterque. The ears are AD, AS and AU (auris dextra, sinistra, utraque). Because the two sets are mistaken for each other, and OD has also meant once daily, ISMP’s list says to write the words.
Every other day. It is on the Joint Commission “Do Not Use” list because a poorly written o makes it look like qd (daily) or qid (four times a day): write “every other day”.
No. This is a study aid for people in pharmacy technician, medical assisting, nursing, billing and coding and health information programs, and for staff who read orders. It does not name a drug, does not tell anyone what to take or give, and your program’s materials and your facility’s own approved abbreviation list come first.
The lookup, the quick answers, the sig examples, the frequency chart, the “Do Not Use” list and the 20 practice questions with your result are free with no sign-up. An email unlocks the bonus: the printable chart and 30 more questions.